Maintain skin structure and support long-term skin performance through collagen remodeling
Vecollage® Fortify L is a skin-identical collagen polypeptide (sh-Polypeptide-69) – identical to a section of human collagen type III, designed to support continuous dermal remodeling and collagen balance, helping maintain firmness, elasticity, and dermal density over time.
It brings longevity science into everyday skincare, enabling products that go beyond correction to support the long-term functional quality of the skin.
What it enables
- Visible anti-aging results that improve over time
- Stronger, more resilient skin structure
- Measurable outcomes supporting credible claims
Benefits at a glance
- Structural remodeling & resilience: Supports collagen structure and dermal density for firmer, more resilient skin
- Wrinkle reduction: Visibly smooths wrinkles across multiple facial areas with progressive improvement over time
- Low dose efficiency: Clinically effective at minimal use level (0.3%)
- Daily care compatibility: Ideal for serums, creams and routine skincare applications
- Clinically proven anti-aging: Substantiated results across key structural endpoints
- Structural skin claims: Supports dermal density, ECM and collagen network positioning
Find out more at https://intobeauty.evonik.com/product_area/?id=578
Product Details & Documents
Product Information
Markets & Applications
A shift in anti-aging expectations
Consumers are increasingly interested in longevity-driven skincare but their trust depends on clear, measurable results, not abstract claims.
A new requirement for modern anti-aging:
- Clinically measurable outcomes
- Longer-term efficacy aligned with skin biology
- A clear connection between mechanism, data, and visible results
Most anti-aging technologies focus on individual aspects of skin appearance, but often without demonstrating structural change in the dermis:
- Traditional collagen (animal-derived) → hydrates at the surface, with limited impact on dermal structure
- Peptides → provide signaling, but often lack long-term clinical proof of structural remodeling
- Hydration actives → deliver instant plumping without affecting collagen or ECM structure
Results
- Improvements can be fast but may be partially cosmetic
- Effects plateau over time
- Limited differentiation across products
Formulator pain points
Formulators need solutions that:
- Deliver clinically measurable outcomes
- Enable credible and differentiated claims
- Connect mechanism → structure → visible results
Supporting collagen balance for long-term structural skin integrity
Dual mechanism targeting ECM balance:
1. Replenishment
- Stimulates the key fibrillar collagen types I & III
- Supports extracellular matrix (ECM) synthesis
2. Protection
- Reduces collagen degradation (MMP regulation)
- Maintains dermal structure
Linked to key biological processes of skin aging
Skin aging involves changes in:
- Collagen and protein homeostasis
- Cellular communication and signaling
- Progressive degradation of extracellular matrix structure
By supporting collagen balance and ECM integrity, Vecollage® Fortify L helps address downstream structural effects of these processes, contributing to:
- Improved dermal density
- Enhanced firmness and elasticity
- Sustained skin quality over time
More detailed molecular pathways and study data are available via intoBeauty.
Designed for high-performance anti-aging formulations requiring measurable results
This active is suited for a wide range of high-performance formulations where collagen support and visible rejuvenation are key:
- Anti-aging and pro-aging skincare
- Dermocosmetic treatments targeting wrinkles and firmness
- Serums, creams, and lotions focused on dermal density and elasticity
- Biomimetic and “skin-identical” product concepts
Its water-based liquid format enables flexible integration across textures and formats.
Matches clean, ethical, and vegan formulation strategies
The ingredient aligns with evolving sustainability and ethical requirements in personal care:
- Produced via precision fermentation using renewable feedstocks
- Vegan-suitable and halal-certified
- Designed for traceability and consistent quality
- Supports clean and ethical beauty positioning
By replacing traditional animal-derived collagen inputs, it enables brands to meet consumer demands for responsible sourcing while maintaining high-performance claims.
Concept inspiration for collagen-focused skincare
Formulation concepts illustrate how this active can be incorporated into finished products:
- Collagen Lifting Cream pairs the ingredient with ceramide technology to support lifting, hydration, and wrinkle reduction.
- Renewed Radiance Serum combines the collagen-polypeptide with a hyaluronic acid mimetic for a lightweight, hydration-focused format.
- CeraColla Renewal Complex integrates multiple biotech actives into a richer cream designed for intensive care.
- Enhanced Beauty Lotion demonstrates use in lighter emulsions for daily care applications.
These concepts highlight the versatility of the ingredient across textures and positioning strategies.
Ready to bring longevity into daily skincare?
With Vecollage® Fortify L, you create products that:
- Deliver visible anti-aging results
- Reinforce skin structure continuously
- Support long-term skin resilience
FAQ
Vecollage® Fortify L is a biotechnology-derived, skin-identical collagen polypeptide (sh-Polypeptide-69) designed to support dermal remodeling and collagen balance. It helps improve skin density, firmness, elasticity, and wrinkle appearance for visible anti-aging results over time.
Traditional collagen ingredients are typically derived from animal sources, such as marine or bovine collagen, and primarily provide surface-level hydration and smoothing benefits.
Vecollage® Fortify L contains a biotechnology-derived polypeptide that is identical to a section of human collagen type III, a key structural collagen naturally present in youthful skin. Unlike traditional collagen, it is designed to support collagen balance and extracellular matrix (ECM) integrity, helping deliver measurable improvements in dermal density, firmness, elasticity, and wrinkle appearance.
Collagen type III is an important structural component of youthful skin, contributing to elasticity, flexibility, and tissue remodeling. Vecollage® Fortify L contains a skin-identical polypeptide - identical to a section of human collagen type III - helping support collagen balance and long-term skin structure.
Vecollage® Fortify L supports skin structure through a dual mechanism:
- Supports collagen types I and III synthesis
- Helps reduce collagen degradation through MMP regulation
Together, these actions help maintain collagen balance and support long-term structural skin integrity.
Vecollage® Fortify L is supported by a comprehensive in vitro, ex vivo, and placebo-controlled clinical program demonstrating both structural skin improvements and visible anti-aging benefits.
In a 60-day double-blind clinical study versus placebo, Vecollage® Fortify L delivered:
- +22% dermal density
- +14% firmness
- +13% elasticity
- –8% wrinkle reduction
These measurable structural improvements translated into a visible benefit: skin appeared up to 6 years younger after 60 days, based on a composite skin youthfulness index combining multiple structural and appearance-related parameters.
Vecollage® Fortify L demonstrates a direct link between collagen remodeling, improved skin structure, and visible anti-aging outcomes.
Dermal density is a key indicator of skin structure. As collagen and extracellular matrix components decline with age, skin can become less firm and more prone to wrinkles.
Unlike appearance-based assessments alone, dermal density measures structural changes within the skin. In a double-blind, placebo-controlled clinical study, Vecollage® Fortify L increased dermal density by 22% after 60 days (vs placebo), demonstrating measurable improvement in skin structure alongside benefits in firmness, elasticity, and wrinkle appearance.
Rather than focusing only on temporary cosmetic effects, Vecollage® Fortify L supports collagen balance and dermal structure over time. By helping maintain skin density, firmness, and elasticity, it contributes to long-term skin performance and visibly healthier-looking skin.
Yes. Vecollage® Fortify L is produced via precision fermentation using renewable feedstocks and is suitable for vegan formulations. It is also halal-certified and supports responsible sourcing strategies.