Evonik has decades of expertise in helping customers identify the right polymer, process technology and formulation solutions to successfully formulate APIs with poor solubility and increase the bioavailability of oral drugs.
Based on comprehensive knowledge in the field of solubility enhancement and thousands of trials in Evonik labs, our formulation and application experts are your reliable partner for finding the right carrier, choosing the best process technology, and setting up the process for new drug developments
Benefits at a glance
- Decades of expertise with poorly soluble APIs
- EUDRAGIT® functional film coating polymers with well defined processing characteristics that make them ideal for improving drug solubility
- For spray drying: EUDRAGIT® polymers are lightly soluble in common solvents and show excellent powder compressibility
- For hot melt extrusion: EUDRAGIT® polymers have excellent thermoplastic properties and broad miscibility with APIs and other excipients
- Proprietary solubility enhancement technology which turns poorly soluble drugs into free-flowing amorphous solid dispersions
- Use of solvent- or melt-based miniaturized screening tools to identify the best carrier, a suitable drug polymer ratio, get a first idea on the solubility trend in relevant dissolution media and learn about stability of the system early on with only very small amounts of API