Your experts in continuous processing - Over 50 years of innovation in continuous manufacturing
Continuous processing is transforming how pharmaceuticals and chemicals are made—especially when it comes to complex or multi-step API (active pharmaceutical ingredient) synthesis. Compared to traditional batch methods, continuous processes offer:
- Improved safety through better control of reaction conditions
- Consistent product quality
- Higher efficiency and yield
- Reduced waste and cost
- Strong regulatory compliance
With more than five decades of experience, Evonik is a pioneer in continuous manufacturing. Today, over two-thirds of our product portfolio is produced using these advanced techniques.
Whether you're looking for a partner for pilot-scale or full commercial API production, Evonik offers complete solutions—from process development to manufacturing. Our expertise includes continuous reactions, separation, and work-up strategies that help you scale quickly, safely, and cost-effectively.
End-to-end continuous processing solutions
We apply continuous technologies wherever they add value—across development, separation, and work-up stages. Our flexible portfolio includes proven processes tailored to your project needs.
By identifying key parameters early, we help you choose the right mix of batch and flow chemistry to:
- Enhance safety
- Maximize purity and yield
- Improve scalability and cost-efficiency
Our experienced team works closely with yours to integrate continuous systems that support fast development, regulatory compliance, and smooth scale-up.
Technologies We Use
Reactors:
- Micro- and milli-reactors
- Loop or tube reactors
- Trickle-bed reactors
- Column reactors
- Continuous Stirred Tank Reactors (CSTR)
Separation & Work-Up:
- Extraction
- Distillation
- Simulated Moving Bed Chromatography (SMB)
- Crystallization
- Centrifugation
- Filtration
Modular pilot plant for continuous processing
Evonik’s new Modular Continuous Pilot (MCP) plant in Hanau, Germany, offers a flexible, cGMP-qualified environment for continuous reactions. Harmonized with other Evonik sites, it supports fast scale-up from lab to commercial production.
The MCP plant handles a wide range of reaction types—including hydrogenations and processes involving extreme temperatures or hazardous gases. It’s designed for safe handling of challenging compounds while meeting strict safety and regulatory standards.
This investment strengthens our contract manufacturing capabilities, helping clients bring products to market faster while maintaining high quality and sustainability.
Supporting you from development to large-scale production
Evonik’s global network of Western-based manufacturing sites and a team of over 500 experts—including engineers, chemists, analysts, and technicians—ensures smooth execution of complex continuous flow projects.
We also offer expertise in complementary technologies such as:
- Organometallic chemistry
- Cryogenic chemistry
- HPAPI (Highly Potent APIs)
- High-purity PEG and mPEGs
ANY QUESTIONS LEFT? JUST CONTACT US.
"Exploring options for the development and manufacture of your cGMP small molecule drug substance or associated intermediates? Reach out and we'll help you make well informed choices as Evonik aims at getting clients practical solutions faster and easier."
Eric Neuffer
Head of Drug Substance Sales
