Scientific publications

Scientific evidence and collaborative insights on methionine bioefficacy

Explore our scientific publications and conference contributions on methionine, nutrient efficacy and animal nutrition. This collection provides access to scientific work developed in collaboration with or with the involvement of Evonik, including research on MetAMINO® and the 65% bioefficacy concept compared with methionine hydroxy analogue products.

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Trial evidence
Bioefficacy science
Scientific insights
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Trial related articles & abstracts

_{Aquaculture | 2022}

Metabolic and nutritional response of Nile tilapia juveniles to dietary methionine sources

British Journal of Nutrition. 2022;127(2):202-213

^{Masagounder et al.}

_{Aquaculture | 2021}

Growth and metabolic response of juvenile Nile tilapia demonstrate DL-Methionine is superior to MHA-Ca

Fish Farming Technology: International Aqua Feed, October 2021

^{Masagounder et al.}

_{Poultry | 2025}

Higher nutritional value of DL-methionine confirmed in growing broilers

24th European Symposium on Poultry Nutrition, 2025, #PS3-251

^{A. Lemme, J. Tyl, H. Kozeluhova, M. Naatjes}

_{Poultry | 2025}

Responses of slow growing broilers to methionine supplementation and methionine sources

Evonik – Facts & Figures 15217, 2025

^{Andreas Lemme}

_{Insects | 2025}

Methionine supplementation affected performance of black soldier fly larvae (Hermetia illucens) and microbial activity

Bornimer Agrartechnische Berichte (111), ISSN 0947-7314 (InsectsPlus 2025, 12th-14th May, Cloppenburg, Germany), Page 71

^{Andreas Lemme and Patrick Klüber}

_{Swine | 2025}

Nitrogen retention was not different in pigs fed diets supplemented with 65 parts of DL-Methionine or 100 parts of MHA-Ca

Journal of Animal Science, Volume 103, Issue Supplement_1, May 2025, Pages 99-100

^{Jessica P. Acosta , S. Maria S. Mendoza , John K. Htoo , Hans H. Stein}

_{Swine | 2024}

Effects of supplemental methionine sources in finishing pig diets on growth performance, carcass characteristics, cutting yields, and meat quality

Translational Animal Science, Volume 8, 2024, txae088

^{Hannah M. Remole, John K. Htoo, S. M. Mendoza, Casey L. Bradley, Ryan N. Dilger, Anna C. Dilger, Bailey N. Harsh}

_{Poultry | 2025}

Effects of methionine sources on performance and productivity in broiler breeders

Poultry Science Association Annual Meeting Abstracts (114th PSA abstract # 337 page 154), presented July 14-17, 2025 Raleigh, North Carolina

^{Fernanda Castro, Corey Wishon, Dannica Wall, Adam Fahrenholz, Victor Naranjo, Lynn Worley-Davis, Allison Pullin}

_{Poultry | 2024}

Relative bioavailability value of DL-2hydroxy-4-methylthio butanoic acid to DL-methionine for growth performance parameters of male broiler from 14 to 28 days of age and 28 to 42 days of age

Poultry Science Association Annual Meeting Abstracts (113th PSA abstract #137 and #169), July 15-18, 2024 Louisville, Kentucky, US

^{G. Aguiar, G. Braga, L. Fonseca, M. Nascimento, D. Cardoso, A. Lourenco, N. Furlani, M. Farias, G. Viana, A. Lemme, J. Dorigam, V. Naranjo, M. Hannas}

_{Poultry | 2026}

Effects of DL-methionine or methionine hydroxy analogue-free acid supplementation on growth performance and carcass yield of broilers fed reduced energy diets with guanidinoacetic acid supplementation

animals, 2026

^{Patrícia Tomazini Medeiros, Andreas Lemme, Victor Naranjo, Mariane Possamai, Rafael Rancatti, Alex Maiorka}

Comparing the relative bioefficacy of MHA products with DL-methionine, related articles & abstracts

_{Poultry | 2024}

Meta-Analyses of Methionine Source Concept Validation Trials in Broilers

animals, 2024

^{Andreas Lemme, Zeyang Li, Juliano Dorigam}

_{Swine | 2025}

Effects of increased dietary supplementation with DL-methionine or with DL-methionine hydroxyl analogue on the intestinal morphology, and intestinal permeability- and immunity-associated gene expression, in growing pigs

Canadian Journal of Animal Science 105:1-8

^{Emmanuel O. Oladejo, Md. Shamimul Hasan, Susan C. Sotak, John K. Htoo, Peixin Fan, James Brett, Jean M. Feugang, and Shengfa F. Liao}

_{Swine | 2024}

Bioavailability of calcium salt of hydroxy analogue of methionine relative to DL-methionine to support growth performance of 11 to 20 kg pigs

Journal of Animal Science, 2024 May 4;102(Suppl 2):115–6

^{B. Jayaraman, J. Morales, M. Rodriguez and J. K. Htoo}

_{Poultry | 2024}

Effects of methionine supplement sources and crude protein on Ross 708 male broiler performance and carcass yield

Journal of Applied Poultry Research, 2024

^{D.R. Boontarue, F.L.S. Castro, C.M. Poholsky, B.S. Liebross, J.W. Boney}

_{Insects | 2026}

Amino acid requirements of neonate larvae of the black soldier fly, Hermetia illucens

Journal of insects and food and feed, 2026

^{C. Sandrock, J. Wohlfahrt, T. Stadtlander, F. Leiber, F. Schindler, M. Hardick, A. Lemme, C. Lambertz}

_{Poultry | 2026}

Understanding methionine bioefficacy: Implications for animal performance and feed costs

Milling and Grain August 2026

^{Andreas Lemme}

_{Poultry | 2024}

Multitissue transcriptomics demonstrates the systemic physiology of methionine deficiency in broiler chickens

Animal Volume 18, Issue 5, 2024

^{Klünemann et al.}

_{Poultry | 2023}

Methionine sources differently affect production of reactive oxygen species, mitochondrial bioenergetics, and growth of murine and quail myoblasts in vitro

current issues in molecular biology, 2023

^{Katja Stange, Toni Schumacher, Claudia Miersch, Rose Whelan , Martina Klünemann, Monika Röntgen}

_{Poultry | 2025}

Effect of DL-methionine and MHA on the performance and gut health of aflatoxin-challenged broilers

Poultry Science Association Annual Meeting Abstracts (114th PSA abstract #300)

^{C. Gayrard, C. Fudge, C. Chongxiao, R. Shanmugasundaram, T. Applegate}

_{Poultry | 2024}

Supplementation of DL-methionine at 65% of MHA-FA supports similar performance in broilers irrespective of dietary crude protein and methionine + cysteine levels

Poultry Science Association Annual Meeting Abstracts, 2024 (113th PSA abstract #170)

^{Zeyang Li, Juliano Dorigam, Andreas Lemme, Gabriel Viana}

Latest research of DL-methionine, related articles & abstracts

_{Swine | 2026}

Preventive–curative functional amino acid–supplemented diet improves health, growth performance, and resilience of growing pigs under an immune challenge

Journal of Animal Science 104, 2026

^{França et al.}

_{Swine | 2025}

Estimating standardized ileal digestible methionine requirements for gilts during gestation using whole-body nitrogen retention and describing plasma creatine, glutathione, and taurine concentrations

Journal of Animal Science 103, 2025

^{Alfonso et al.}

_{Poultry | 2025}

Transport and expression of transporters for 3-O-methyl-D-glucose and L-methionine along the intestine of broiler chickens receiving different methionine supplements

Poultry Science, 2025

^{Riedel et al.}

_{Insects | 2024}

Rethinking amino acid nutrition of black soldier fly larvae (Hermetia illucens) based on insights from an amino acid reduction trial

insects, 2024

^{Andreas Lemme, Patrick Klüber}

_{Poultry | 2024}

Betaine cannot replace methionine

Expert Note, July 2026

^{Andreas Lemme}

Unlocking the full potential of MetAMINO® –
Related articles & insights from AMINO Services

_{Poultry | 2026}

An advanced approach for replacing methionine hydroxy analogue with DL-methionine suggests considerable feed cost savings beyond product price-related savings

AMINONews, October 2026

^{Dr. Andreas Lemme, Global Senior Expert Poultry, Evonik; Dr. Tom Han, Technical Service Manager APAC, Evonik}

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Key to precisely balanced diets – How to implement precision nutrition

AMINONews, October 2026

^{Dr. Markus Wiltafsky-Martin, Director Service Commercialization, Evonik}

₂₀₂₆

AMINONIR: Near-infrared spectroscopy (NIR) analytical service – the next level

AMINONews, October 2026

^{Dr. Markus Wiltafsky-Martin, Director Service Commercialization, Evonik}

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Incorporating liquid MHA-FA into feed can result in longer mixing times compared to dry DL-methionine

AMINONews, October 2026

^{Christian Rabe, Head of Feed Technology, Evonik}

Discover older editions of the MetAMINO® Atlas

MetAMINO® Atlas Edition 2

The 2nd edition of MetAMINO® Atlas presents 19 performance trials conducted in 12 countries on 4 continents with more than 2 million animals. It shows that the 65% bioeﬃcacy concept is universally applicable.

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Discover the first edition of our MetAMINO® ATLAS

In the MetAMINO® Atlas, Evonik has summarized the results of 15 performance trials that were conducted around the globe under different climatic and agricultural conditions. The MetAMINO® Atlas provides a balanced selection of academic research and field trials with feed for broiler chickens, laying hens, swine and fish.

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Learn more about Animal Nutrition

MetAMINO® ATLAS

Lorem ipsum discover the MetAMINO® ATLAS presents 19 performance trials conducted in 12 countries on 4 continents with more than 2 million animals. It shows that the 65% bioeﬃcacy concept is universally applicable.

MetAMINO®

Less is more: Reduce feed costs and increase profitability with MetAMINO® – the essential building block for optimized animal nutrition

Scientific evidence and collaborative insights on methionine bioefficacy

Further information

Trial related articles & abstracts

Responses of slow growing broilers to methionine supplementation and methionine sources

Comparing the relative bioefficacy of MHA products with DL-methionine, related articles & abstracts

Latest research of DL-methionine, related articles & abstracts

Unlocking the full potential of MetAMINO® – Related articles & insights from AMINO Services

Discover older editions of the MetAMINO® Atlas

MetAMINO® Atlas Edition 2

Discover the first edition of our MetAMINO® ATLAS

Get in touch with our experts

Learn more about Animal Nutrition

MetAMINO® ATLAS

MetAMINO®

Unlocking the full potential of MetAMINO® –
Related articles & insights from AMINO Services