Oral Drug Delivery - Formulation & Development Services

At Evonik, we work with pharmaceutical innovators to solve the real-world challenges of oral drug delivery. Our formulation and development services are built to improve solubility, bioavailability, and stability—so your oral drug products are ready for clinical success and designed with patients in mind.

Oral drug delivery remains the most preferred route for patients—but it’s also one of the most complex for developers. Poor solubility, low bioavailability, and gastrointestinal instability can derail even the most promising compounds.

That’s where we come in. Evonik offers a full range of oral formulation services that help you move faster, reduce development risk, and unlock the full potential of your molecule. Whether you're starting with a new chemical entity or optimizing an existing formulation, we bring the expertise, technologies, and infrastructure to support your success.Our Oral Drug Delivery Services

Make confident decisions early on

Before committing to full-scale development, it’s critical to understand whether your oral drug formulation concept is technically and commercially viable. Evonik’s Feasibility Services provide a structured, data-driven approach to help you make informed decisions early in the development process—saving time, reducing risk, and increasing the likelihood of success.

Our feasibility studies are designed to:

• Evaluate formulation strategies for oral drug delivery, including solubility enhancement, controlled release, and targeted delivery.
• Screen enabling technologies such as hot melt extrusion, spray drying, and EUDRATEC® platforms to identify the most promising approach.
• Assess manufacturability and scalability to ensure smooth transition from lab to clinical supply.
• Generate early prototypes and conduct pre-formulation testing to support go/no-go decisions.
• Provide regulatory and analytical guidance to align with your development goals and timelines.

Whether you’re working with a new chemical entity (NCE) or reformulating an existing compound, our feasibility services help you define the optimal path forward—scientifically, technically, and commercially.

Seamlessly from concept to clinical supply

We offer end-to-end formulation development services for solid oral dosage forms, supporting pharmaceutical companies from early-stage concept through to clinical trial supply. Our approach combines deep scientific expertise with advanced technologies to create customized, scalable, and regulatory-compliant formulations.

Our formulation development services include:

• Pre-formulation and excipient screening to identify optimal ingredient combinations for stability, performance, and manufacturability.
• Prototype development using enabling technologies such as hot melt extrusion, spray drying, and EUDRATEC® platforms.
• Controlled release, enteric protection, and targeted delivery solutions tailored to your drug’s pharmacokinetic profile and therapeutic goals.
• Process development and scale-up under GMP conditions to ensure smooth transition from lab to clinical manufacturing.
• Analytical method development and stability testing to support regulatory submissions and quality assurance.

Our scientists work closely with your team to design oral formulations that address key challenges such as poor solubility, low bioavailability, gastrointestinal degradation, and patient compliance. Whether you’re developing a new molecule or improving an existing product, we provide the technical insight and infrastructure to accelerate your path to market.

Proven platforms to solve complex delivery problems.

Evonik provides a comprehensive portfolio of advanced oral drug delivery technologies that address the most pressing formulation challenges in the pharmaceutical industry. These proprietary platforms are designed to improve solubility, targeted release, and patient-centric performance.

Evonik’s Fast Enteric Release technology enables rapid drug release in the upper small intestine, bypassing the stomach to protect acid-sensitive APIs. This platform supports faster onset of action, enhanced bioavailability, and precise pH-triggered release.

Our Sustained Colonic Release technology enables targeted and prolonged drug release in the colon. It is ideal for local treatment of colonic diseases or systemic delivery of drugs with narrow absorption windows. The platform supports once-daily dosing and improved therapeutic consistency.

Evonik offers multiple technologies to address the challenge of poorly water-soluble APIs:

• EUDRATEC® SoluFlow: A cutting-edge microparticle-based technology that enables the production of amorphous solid dispersions using spray drying. It enhances bioavailability while offering scalability and process efficiency for industrial manufacturing.
• Hot Melt Extrusion (HME) and Spray Drying: Proven techniques for creating stable amorphous solid dispersions that improve dissolution rates and systemic exposure.

Evonik also offers:

• Alcohol-resistant coatings to prevent dose dumping and enhance formulation safety.
• Microbiome-targeted delivery systems that enable precise release in the gut microbiota environment—supporting the development of next-generation therapeutics.

Oral drug delivery presents a range of formulation challenges that can limit therapeutic success. At Evonik, we specialize in overcoming these barriers through advanced technologies and tailored formulation strategies that improve drug performance and patient outcomes.

• Low solubility: Many APIs suffer from poor water solubility, limiting absorption. We apply technologies such as amorphous solid dispersions, hot melt extrusion, spray drying, and EUDRATEC® SoluFlow to significantly enhance solubility and dissolution rates.
• Poor bioavailability: Our controlled and targeted release systems optimize drug exposure and improve systemic absorption.
• Instability in the GI tract: Sensitive APIs are protected using enteric coatings and pH-dependent release systems to ensure delivery at the right site.
• Patient compliance: We design oral dosage forms that are easier to take, reduce dosing frequency, and improve therapeutic consistency.

Let's move your oral drug product forward

Whether you need feasibility support, formulation development, or clinical trial manufacturing, Evonik is your trusted partner in oral drug innovation. Our global network of experts, technologies, and GMP facilities ensures your project moves forward with confidence.

Talk to our team today to explore how we can support your next oral drug innovation.