PhytoChol® Inject: parenteral grade cholesterol for nucleic acid therapeutics and mRNA vaccines beyond COVID-19
Cholesterol is an important functional excipient for parenteral mRNA-based drug delivery systems. As part of the lipid coating that protects the mRNA, cholesterol can modulate drug release, enhance the ability of the drug formulation to penetrate cell membranes, and provide a stabilization effect.
PhytoChol® Inject is Evonik’s high-purity, vegetal-derived cholesterol suitable for parenteral applications. This ultra-low-endotoxin cholesterol provides a first-rate alternative to traditional animal-based cholesterol, is USP-NF, Ph.Eur and JP compliant, and can be provided in the quantities required for lipid nanoparticle (LNP) manufacturing.
An increasing number of companies are moving away from animal-derived materials. Regulatory agencies often require proof that any animal material is safeguarded against the risk of disease transmission. Today, many patients prefer non-animal derived products for ethical, religious, or personal reasons.
For the past year, demand for lipids (including cholesterol) has far exceeded supply. Evonik has responded quickly to this market need to meet the increased demand for cholesterol for pharmaceutical liposomal drug delivery. PhytoChol® Inject can provide you with a reliable source of high-quality, multi-compendial, non-animal-derived lipid excipient.
From drug delivery to cell culture, our system solution PhytoChol® provides you with the following advantages:
- Completely non-animal derived
- Secure and stable supply
- Large-scale manufacturing
- High-purity, consistent quality
- Western-based manufacturing
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"Our global team of formulation experts is ready to support you with all questions around our product and service portfolio for parenteral drug delivery. Contact us to profit from more than 30 years of application know-how!"
Ahmet Alici
Business Manager
