Biopharma & Bioprocessing

What if your cell culture media formulation could do more - accelerate cell productivity, intensify media, and simplify the upstream bioprocess?

Evonik offers high‑quality, non‑animal‑derived cell culture ingredients that help media providers and biopharma companies achieve higher cell growth, viability, and titers.

Do you focus on downstream process enhancement or final formulation? Leverage our exceptionally pure ingredients to elevate biopharmaceutical manufacturing and formulations.

Seeking more consistent and efficient production of biopharmaceuticals? Our expertise in media formulation and application support enables the optimization of cell culture media and supports improved productivity.

cQrex® peptides are chemically defined ingredients designed to manage the supply of critical amino acids to cells by solving the stability and solubility challenges of L-glutamine, L-tyrosine and L-cysteine. As an antioxidant, cQrex® AKG protects cells against oxidative damage and stimulates cell growth.

Our cQrex® portfolio includes:

• cQrex® AQ L‑Alanyl‑L‑glutamine
• cQrex® GQ Glycyl‑L‑glutamine hydrate
• cQrex® GY Glycyl‑L‑tyrosine dihydrate
• cQrex® AY L‑Alanyl‑L‑tyrosine trihydrate
• cQrex® AC N,N’‑di‑L‑Alanyl‑L‑cystine H₂O
• cQrex® KC N,N’‑di‑L‑Lys‑L‑CySS 2HCl H₂O
• cQrex® AKG Alpha‑Ketoglutaric acid

Key benefits of cQrex®

• Process efficiency - boosted cell viability, productivity, and antibody titer
• Concentrated media - enhanced nutrients stability and solubility for intensified bioproduction
• Simplified bioprocess - transition from a dual-feed to a single-feed system at neutral pH to reduce production cost

Cholesterol serves as a structural component of cell membranes. Supplementation of PhytoChol® BioPharma, our highly pure and non-animal-derived cholesterol, supports cell growth and enhances outcomes in the production of proteins, viral vectors and vaccines. PhytoChol® BioPharma is suitable for a wide range of cell lines including NS0, insect, Vero cells and mesenchymal stem cells (MSCs).

MaxiPure® Polysorbate 80 is a non-ionic surfactant with superior purity and exceptional clarity. It can be used in injectable formulations and in biopharmaceutical applications to ensure solubility of hydrophobic drugs, maintain protein stability and support downstream bioprocessing.

CreaCyte® rHSA by InVitria is a portfolio of recombinant human serum albumins designed to meet the diverse needs of biopharmaceutical manufacturing. Evonik is partnering with InVitria to offer these highly pure, animal-origin-free albumin products ensuring a consistent, chemically defined alternative to animal-derived albumin.

The eviCHO Expression Kit is made for protein expression in CHO-K1 cells and includes all the essential, pre-validated components for professional CHO expression. Evonik has partnered with evitria to launch this comprehensive, ready-to-use CHO expression system designed to simplify transient protein expression while delivering exceptional results.

As building blocks of proteins, amino acids are key components of cell culture media used in the production of biopharmaceuticals such as monoclonal antibodies. Rely on our wide range of pharmaceutical-grade amino acids which meet stringent quality and regulatory requirements.

Evonik offers a range of non-animal-derived carbohydrates to enable a higher flexibility in mammalian cell culture. Tailor the energy supply by using other carbohydrates than D-Glucose and optimize the glycosylation profile of therapeutic proteins, helping you achieve higher product quality.