Transform Intermediates into High-Purity Commercial Products
Evonik Rexim is a European CDMO specializing in downstream processing of fermentation- and synthesis-derived small molecules. With decades of expertise in amino acids, peptides, polysaccharides, and specialty ingredients, we help customers transform intermediates into high-purity, market-ready products while accelerating development and commercialization.
From process development and chemical modification to purification, GMP manufacturing, packaging, and supply, we provide the expertise and infrastructure needed to accelerate commercialization and reduce operational complexity.
From Intermediate to Commercial Product
Developing a molecule is only part of the journey. Achieving the required purity, quality, stability, and regulatory compliance for commercialization often represents the greatest manufacturing challenge.
Evonik Rexim is a European CDMO specialized in downstream processing of fermentation- and synthesis-derived molecules. With decades of experience in amino acids, peptides, polysaccharides, and specialty ingredients, we support customers throughout the entire downstream value chain, helping them bring products to market faster while minimizing investment in internal processing capabilities.
Your Benefits
- High-purity finished products suitable for commercial applications
- Accelerated path to commercialization
- Reduced investment in downstream processing infrastructure
- Flexible scale-up from development to commercial supply
- Reliable European manufacturing partner
- Proven expertise across multiple molecule classes
Comprehensive Downstream Processing Capabilities
Our integrated service offering covers critical downstream processing operations required to transform intermediates into finished products.
We provide specialized chemical processing capabilities to tailor product properties and support downstream manufacturing requirements.
Capabilities include:
- Acetylation
- Hydrolysis
- Process optimization and scale-up
Purity is often the critical success factor for market approval and customer acceptance.
Our purification capabilities include:
- Ion exchange chromatography
- Industrial-scale purification processes
- Removal of process-related impurities
- High-purity product isolation
Modern filtration technologies help achieve demanding purity specifications while improving process efficiency.
Capabilities include:
- Ultrafiltration
- Bacterial reduction
- Endotoxin removal
- Product concentration
To prepare products for commercial use, we offer a wide range of finishing technologies.
Capabilities include:
- Crystallization
- Evaporation
- Drying
- Spray drying
- Milling
Our services extend beyond manufacturing to support reliable product delivery.
Capabilities include:
- GMP-compliant packaging
- Supply chain support
- Commercial product supply
Molecules We Support
Our teams have extensive experience processing a broad range of complex molecules and specialty ingredients.
Applications include:
- Amino acids
- Peptides
- Polysaccharides
- Specialty ingredients
- Fermentation-derived products
- Synthesis-derived products
Flexible Scale-Up from Development to Commercial Supply
Successful commercialization requires more than technical expertise. It requires the ability to transfer, optimize, and scale processes reliably.
At Evonik Rexim, we support projects from development-scale manufacturing through commercial production. Our downstream processing expertise enables customers to reduce development timelines, minimize technical risks, and secure a reliable supply chain as product demand grows.
Quality and Regulatory Excellence
Quality and compliance are integrated into every stage of our manufacturing operations.
Our facilities operate according to internationally recognized quality and regulatory standards, including:
- GMP compliance (ICH Q7)
- ISO 9001
- ISO 14001
- ISO 50001
- FSSC 22000
- HACCP compliance
We support demanding product quality requirements through:
- USP compliance
- EP compliance
- JP compliance
- FCC compliance
- Controlled microbial levels
- Controlled endotoxin levels
- BSE/TSE-related documentation
- Kosher certification
- Halal certification
- Non-animal origin declarations
Navigating global regulatory requirements can be challenging. Our experts support customers with:
- Drug Master Files (DMFs)
- Certificates of Suitability (CEPs)
- REACH registration
- Global registration support
- Regulatory consulting
- Documentation maintenance
Our experience includes support for customer interactions and requirements related to major regulatory authorities worldwide.
At A Glance: Why Partner with Evonik Rexim?
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Frequently asked questions (FAQ)
Downstream processing includes all manufacturing steps required to purify, modify, concentrate, and formulate a product after fermentation or chemical synthesis.
Typical products include amino acids, peptides, polysaccharides, specialty ingredients, and other fermentation- or synthesis-derived molecules.
Evonik provides industrial-scale ion exchange chromatography, ultrafiltration, crystallization, drying, spray drying, and milling services.
Yes. We support customers from development-scale activities through commercial manufacturing and supply.
Ion exchange chromatography is a purification technology used to separate target molecules from impurities, helping achieve high product purity and consistent quality.
Ultrafiltration can be used for concentration, bacterial reduction, endotoxin removal, and purification of process streams.
Yes. Manufacturing operations are performed in accordance with GMP requirements and supported by comprehensive quality systems.
Yes. Our experts support DMFs, CEPs, registrations, compliance documentation, and regulatory consulting activities.
Yes. Services include chemical modification processes such as acetylation and hydrolysis.
Outsourcing downstream processing allows companies to leverage specialized expertise, reduce capital investment, accelerate commercialization, and access established manufacturing and quality infrastructures.
