Boost Cell Culture Performance with D-Galactose and D-Mannose
Evonik offers a portfolio of high-purity, plant-derived specialty carbohydrates designed to enhance the performance of cell culture media in biopharmaceutical production. Our D-Galactose and D-Mannose products provide a balanced energy supply and serve as critical building blocks for protein glycosylation, helping you achieve superior product quality and process efficiency.
Functions and Applications of D-Galactose and D-Mannose in Cell Culture
In traditional cell culture, D-Glucose is the primary energy source. However, its rapid consumption often leads to excessive lactate formation, which can impair cell growth and productivity. D-Galactose and D-Mannose are metabolized more slowly, offering a controlled energy release that supports healthier cell cultures and reduces metabolic stress.
These monosaccharides can be used to partially or fully replace glucose, resulting in:
- Reduced lactate accumulation
- Improved cell viability
- Enhanced protein expression
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Why Choose Evonik’s Specialty Carbohydrates?
Balanced Energy Supply
Unlike D-Glucose, which is rapidly consumed and can lead to excessive lactate formation, D-Galactose and D-Mannose are metabolized more slowly. This helps maintain a stable metabolic environment, reducing toxic by-products and improving overall cell viability.
Tailored Glycosylation Profiles
Both carbohydrates play a key role in modulating glycosylation, a crucial quality attribute for therapeutic proteins. Supplementing your media with D-Galactose or D-Mannose can enhance N-linked glycan structures, improving galactosylation and sialylation in CHO cell cultures.
High Purity & Regulatory Compliance
Evonik’s carbohydrates are supplied as ≥99% pure powders, compliant with USP and Ph. Eur. monographs, and manufactured under strict quality controls. They are non-animal derived, making them ideal for chemically defined media formulations.
Applications
- Production of monoclonal antibodies
- Development of biosimilars
- Optimization of CHO cell cultures
- Tailoring glycosylation profiles for therapeutic proteins
Partner with Evonik
With over six decades of expertise in cell culture ingredients, Evonik is a trusted partner to leading biopharma companies worldwide. Our robust supply chain, and deep technical know-how ensure consistent quality and performance across your cell culture platforms.
Ready to optimize your media? Contact our experts or learn more about our full cell culture solutions.
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"If you are looking for ways to more efficient bioprocessing and improved performance, our innovative cell culture solutions will be of great value to you. Contact us to find out how we can support and meet your needs."
Kristina Klinker
Business Development Manager
